Early T-cell precursor leukemia: questions of diagnosis, treatment and description of own clinical case

Early T-cell precursor leukemia (early precursor, ETP-ALL) is a new subvariant of acute lymphoblastic (ALL). Tumor blasts have unique phenotype, including signs both stem and myeloid cells. This fact significantly complicates differential diagnosis. Cytogenetic molecular biological features cells in ETP-ALL are the most important diagnostic criteria. Nowadays leading scientific international groups pediatric conduct researches to develop treatment protocols for or optimize existing chemotherapy regimens by targeted drugs (bortezomib, ruxolitinib, venetoclax). Currently, hematopoietic cell transplantation mandatory option ETP-ALL. Targeted CAR-T-cell (chimeric antigen receptor T-cells) therapy perspective ways posable treatment. In this article there summarized data on diagnosis description successful patient with